Cellxpress
Autonomous Organoid Culture

In the SDL Bio.LAB, we will drive forward the automated production of large quantities of stem cells from various organisms and induced pluripotent stem cells from patients. This also includes the automated and autonomous production of standardized organoids, tumoroids, assembloids, 3D tissues and disease models. A particular strength of the KIT is the development of organoids with bioelectronics and vascularization. In addition to fully automated organoid production, Bio.MAT is complemented by automated confocal spinning disc microcscopy, label-free RAMAN imaging and FACS/spatial transcriptomics/multiplexing and impedance spectroscopy  to enable high-resolution determination of biomarkers and gene expression profiles in the individual cells of tissues and their interactions with intelligent biomaterials. The  SDL will link the Bio.LAB with the already emerging Self Driving Labs for the screening of novel biomaterials (Bio.Mat), Chem.ASAP, BIO.CAR, Robo.COAT and the Bio.NMR  and provide the necessary cell material for these labs

 

The Bio.LAB is one of worldwide 3 fully autonomous experimental systems that is closely connected to our Bio.MAT SDL to enable the development of novel printable bioinks for tissue and organ reconstruction. By incorporating automation technologies, the SDL enables rapid experimentation and optimization cycles that significantly shorten the development time of biomaterials, including cellular materials, and increase efficiency. The autonomous nature of the lab enables continuous operation and high-throughput experimentation with minimal manual intervention. The Self Driving Lab Bio.LAB is not only intended to perform routine tasks, but robotics is an integral part of the experimental setup. The robots will collect data in real time, evaluate experiments and - supported by artificial intelligence - actively change their processes.

Tissue Models and Organoids KIT
iPSC based intestinal organoids